|
KMID : 0378119900170020491
|
|
Chungnam Medical Journal
1990 Volume.17 No. 2 p.491 ~ p.496
|
|
|
Clinical Significance of the Determination of SCC Tumor Marker in Patients with Squamous Cell Carcinoma of the Uterine Cervix
|
|
남상륜/Nam, Sang-Lyun
이종미/Lee, Jong-Mi
|
|
|
Abstract
|
|
|
Serum squamous cell carcinoma-related antigen (SCC) level was measured in 71 patients with cervical cancer (62 of primary and 9 recurrent cervical cancer). The distribution of the clinical stages of cervical cancer were 23 in stage Ⅰ, 28 stage Ⅱ, 10 stage Ⅲ, and 1 stage Ⅳ.
According to our results and those of other authors, the normal value of serum SCC was less than 2 ng/ml.
In patients with squamous cell carcinoma of the cervix, the pretreatment positive rate of serum SCC was 55.8％ (29/52). 72.4％ (21/29) in keratinizing type and 34.8％ (8/23) in nonkeratinizing type. And in adenosquamous cell carcinoma, the positive rate was 50％, adenocarcinoma 33.3％, and small cell carcinoma 0％.
The elevation of the serum SCC values correlated with the clinical stages and the size of the primary tumors.
The positive rates of serum SCC level were higher according to the stages, being 30.4％, 57.1％, 80％, 100％ for stages Ⅰ to Ⅳ respectively. And the absolute values of SCC were significantly higher in the sera of patients with stage Ⅱ and Ⅲ cervical cancer(5.911± 9.809 ng/ml and 8.440± 11.331 ng/ml) When compared to those with stage I cancer (1.796± 1.511 ng/ml).
The positive rate in primary cervical cancer was 50％ (31/62) and 100％ (9/9) in recurrent cervical cancer.
Follow-up studies with various stages showed that the antigen was useful in tracking the clinical course of disease after surgery or. radiotherapy. After operation the elevated serum SCC levels returned to normal range, but after radiation or chemotherapy the titer did not decrease in some patients.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|